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Micron Document

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<table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">NOS1</th></tr><tr><td colspan="4" style="text-align:center"><span typeof="mw:File"></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Available structures</th></tr><tr><th rowspan="2" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;width:43px"><a href="Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit">Ortholog search: <span class=""><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=Q9Z0J4%20or%20P29475">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:Q9Z0J4,P29475">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="text-align:center"><th colspan="2" style="background-color:light-dark(#ddd, #404244) !important;color:inherit">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><p><span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4D1N">4D1N</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4UCH">4UCH</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4UH5">4UH5</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4UH6">4UH6</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4V3U">4V3U</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/5ADF">5ADF</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/5ADG">5ADG</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/5ADI">5ADI</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/5FVX">5FVX</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/5FVW">5FVW</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/5FVU">5FVU</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/5FVV">5FVV</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Identifiers</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><span class=""><a href="Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:light-dark(#eee, #27292d) !important;color:inherit"><span class=""><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/7872">NOS1</a></span>, IHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOS, nitric oxide synthase 1</td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">External IDs</th><td colspan="3" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class=""><a href="Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/163731">163731</a>; <a href="Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:97360">97360</a>; <a href="HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=37327">37327</a>; <a href="GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=NOS1">NOS1</a>; <a href="Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000089250">NOS1 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class=""><a href="Chromosome_12_(human)" class="mw-redirect" title="Chromosome 12 (human)">Chromosome 12 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"></span><div style="position: absolute; left: 253.54289422191px; top: 2px; padding: 0;"><span typeof="mw:File"></span></div><div style="position: absolute; left: 259.5px; top: 19px; padding: 0;"><span typeof="mw:File"></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">12q24.22</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">117,208,142 <a href="Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">117,452,170 <a href="Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">Chromosome 5 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"></span><div style="position: absolute; left: 223.20436130478px; top: 2px; padding: 0;"><span typeof="mw:File"></span></div><div style="position: absolute; left: 229.2px; top: 19px; padding: 0;"><span typeof="mw:File"></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">5 F|5 57.29 cM</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">117,919,097 <a href="Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="">118,096,905 <a href="Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="Human_genome" title="Human genome">Human</a></b></th><th><b><a href="Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000089250">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">body of tongue</li><br><li style="line-height: 137%;">biceps brachii</li><br><li style="line-height: 137%;">Skeletal muscle tissue of biceps brachii</li><br><li style="line-height: 137%;">Skeletal muscle tissue of rectus abdominis</li><br><li style="line-height: 137%;">muscle of thigh</li><br><li style="line-height: 137%;">pons</li><br><li style="line-height: 137%;">gastrocnemius muscle</li><br><li style="line-height: 137%;">spinal ganglia</li><br><li style="line-height: 137%;">buccal mucosa cell</li><br><li style="line-height: 137%;">vastus lateralis muscle</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000029361">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">anterior amygdaloid area</li><br><li style="line-height: 137%;">pontine nuclei</li><br><li style="line-height: 137%;">subiculum</li><br><li style="line-height: 137%;">digastric muscle</li><br><li style="line-height: 137%;">temporal muscle</li><br><li style="line-height: 137%;">mammillary body</li><br><li style="line-height: 137%;">dorsal tegmental nucleus</li><br><li style="line-height: 137%;">ventromedial nucleus</li><br><li style="line-height: 137%;">lateral hypothalamus</li><br><li style="line-height: 137%;">sternocleidomastoid muscle</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class=""><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000089250">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"></span><br><br><span typeof="mw:File"></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class=""><a rel="nofollow" class="external text" href="http://biogps.org/gene/4842/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Molecular function</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="">

<ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0044325">transmembrane transporter binding</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0034617">tetrahydrobiopterin binding</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050661">NADP binding</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046870">cadmium ion binding</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010181">FMN binding</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046872">metal ion binding</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0020037">heme binding</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016491">oxidoreductase activity</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0097110">scaffold protein binding</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005516">calmodulin binding</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0017080">sodium channel regulator activity</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050660">flavin adenine dinucleotide binding</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0034618">arginine binding</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004517">nitric-oxide synthase activity</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0003958">NADPH-hemoprotein reductase activity</a></li></ul>

</div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Cellular component</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="">

<ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrane</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001917">photoreceptor inner segment</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030315">T-tubule</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045202">synapse</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1990425">ryanodine receptor complex</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005739">mitochondrion</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048471">perinuclear region of cytoplasm</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005901">caveola</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005856">cytoskeleton</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042995">cell projection</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043197">dendritic spine</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030018">Z discdkac</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0033017">sarcoplasmic reticulum membrane</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045121">membrane raft</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016529">sarcoplasmic reticulum</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042383">sarcolemma</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005829">cytosol</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005737">cytoplasm</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005654">nucleoplasm</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005886">plasma membrane</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032991">protein-containing complex</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0044305">calyx of Held</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005634">nucleus</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0012506">vesicle membrane</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0014069">postsynaptic density</a></li></ul>

</div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Biological process</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="">

<ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0033555">multicellular organismal response to stress</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031284">positive regulation of guanylate cyclase activity</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0002028">regulation of sodium ion transport</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0098735">positive regulation of the force of heart contraction</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051346">negative regulation of hydrolase activity</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006941">striated muscle contraction</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050767">regulation of neurogenesis</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051612">negative regulation of serotonin uptake</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045893">positive regulation of transcription, DNA-templated</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0018119">peptidyl-cysteine S-nitrosylation</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045454">cell redox homeostasis</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006527">arginine catabolic process</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043267">negative regulation of potassium ion transport</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007263">nitric oxide mediated signal transduction</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010523">negative regulation of calcium ion transport into cytosol</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007520">myoblast fusion</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1902514">regulation of calcium ion transmembrane transport via high voltage-gated calcium channel</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0060314">regulation of ryanodine-sensitive calcium-release channel activity</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1903779">regulation of cardiac conduction</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006809">nitric oxide biosynthetic process</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1902307">positive regulation of sodium ion transmembrane transport</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071363">cellular response to growth factor stimulus</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042136">neurotransmitter biosynthetic process</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035066">positive regulation of histone acetylation</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051926">negative regulation of calcium ion transport</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0055117">regulation of cardiac muscle contraction</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045944">positive regulation of transcription by RNA polymerase II</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001666">response to hypoxia</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009408">response to heat</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045776">negative regulation of blood pressure</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0098924">retrograde trans-synaptic signaling by nitric oxide</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042311">vasodilation</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0140196">positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0099163">synaptic signaling by nitric oxide</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009725">response to hormone</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032496">response to lipopolysaccharide</a></li>

<li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0033138">positive regulation of peptidyl-serine phosphorylation</a></li></ul>

</div></td></tr><tr><td colspan="4" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=4842&rn=1">4842</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=18125&rn=1">18125</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000089250;db=core">ENSG00000089250</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000029361;db=core">ENSMUSG00000029361</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P29475">P29475</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"></th></tr><tr><td colspan="1"><p class=""><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q9Z0J4">Q9Z0J4</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class=""></th></tr><tr><td colspan="1"><p><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_000620">NM_000620</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001204213">NM_001204213</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001204214">NM_001204214</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001204218">NM_001204218</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class=""></th></tr><tr><td colspan="1"><p><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_008712">NM_008712</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (protein)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class=""></th></tr><tr><td colspan="1"><p><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_000611">NP_000611</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001191142">NP_001191142</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001191143">NP_001191143</a><br><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001191147">NP_001191147</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class=""></th></tr><tr><td colspan="1"><p><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_032738">NP_032738</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Location (UCSC)</th><td><span class=""><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr12:117208142-117452170">Chr 12: 117.21 – 117.45 Mb</a></span></td><td><span class=""><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr5:117919097-118096905">Chr 5: 117.92 – 118.1 Mb</a></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="PubMed" title="PubMed">PubMed</a> search</th><td><span class=""><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class=""><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><a href="Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q18030177" class="extiw external" title="d:Q18030177">View/Edit Human</a></td><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q18252682" class="extiw external" title="d:Q18252682">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table>

<p><b>Nitric oxide synthase 1 (neuronal)</b>, also known as <b>NOS1</b>, is an <a href="Enzyme" title="Enzyme">enzyme</a> that in humans is encoded by the <i>NOS1</i> <a href="Gene" title="Gene">gene</a>.<sup id="cite_ref-pmid1385308_5-0" class="reference"><a href="#cite_note-pmid1385308-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid7682706_6-0" class="reference"><a href="#cite_note-pmid7682706-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup>

</p>

<div class="mw-heading mw-heading2"><h2 id="Function">Function</h2></div>

<p><a href="Nitric_oxide_synthase" title="Nitric oxide synthase">Nitric oxide synthases</a> (<a href="Enzyme_Commission_number" title="Enzyme Commission number">EC</a> <a rel="nofollow" class="external text" href="https://enzyme.expasy.org/EC/1.14.13.39">1.14.13.39</a>) (NOSs) are a family of <a href="Synthase" title="Synthase">synthases</a> that <a href="Catalysis" title="Catalysis">catalyze</a> the production of <a href="Nitric_oxide" title="Nitric oxide">nitric oxide</a> (NO) from <a href="L-arginine" class="mw-redirect" title="L-arginine">L-arginine</a>. NO is a chemical messenger with diverse functions throughout the body depending on its enzymatic source and tissue localization. In the brain and peripheral nervous system, where NOS1 is largely present, NO displays many properties of a <a href="Neurotransmitter" title="Neurotransmitter">neurotransmitter</a> and may be involved in <a href="Long_term_potentiation" class="mw-redirect" title="Long term potentiation">long term potentiation</a>. It is implicated in <a href="Neurotoxicity" title="Neurotoxicity">neurotoxicity</a> associated with <a href="Stroke" title="Stroke">stroke</a> and neurodegenerative diseases, neural regulation of smooth muscle, including <a href="Peristalsis" title="Peristalsis">peristalsis</a> and sphincter relaxation, and penile erection. NO is also responsible for <a href="Endothelium-derived_relaxing_factor" title="Endothelium-derived relaxing factor">endothelium-derived relaxing factor</a> activity regulating blood pressure as produced from its related enzyme NOS3. In <a href="Macrophage" title="Macrophage">macrophages</a>, NO mediates tumoricidal and bactericidal actions, as produced from its related enzyme NOS2. Various pharmacological inhibitors of NO synthases (NOS) block these effects, but further distinction of their function has been elucidated by animal models in which these specific genes have been inactivated. Neuronal NOS (NOS1), Endothelial NOS (NOS3), and Inducible NOS <a href="Nitric_oxide_synthase_2A" class="mw-redirect" title="Nitric oxide synthase 2A">macrophage NOS</a> are distinct isoforms.<sup id="cite_ref-pmid1379716_7-0" class="reference"><a href="#cite_note-pmid1379716-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Both the neuronal and the macrophage forms are unusual among oxidative enzymes in requiring several electron donors: <a href="Flavin_adenine_dinucleotide" title="Flavin adenine dinucleotide">flavin adenine dinucleotide</a> (FAD), <a href="Flavin_mononucleotide" title="Flavin mononucleotide">flavin mononucleotide</a> (FMN), <a href="NADPH" class="mw-redirect" title="NADPH">NADPH</a>, and <a href="Tetrahydrobiopterin" title="Tetrahydrobiopterin">tetrahydrobiopterin</a>.<sup id="cite_ref-entrez_8-0" class="reference"><a href="#cite_note-entrez-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup>

</p>

<div class="mw-heading mw-heading2"><h2 id="Clinical_significance">Clinical significance</h2></div>

<p>It has been implicated in <a href="Asthma" title="Asthma">asthma</a>,<sup id="cite_ref-pmid10641565_9-0" class="reference"><a href="#cite_note-pmid10641565-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid16238787_10-0" class="reference"><a href="#cite_note-pmid16238787-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> <a href="Schizophrenia" title="Schizophrenia">schizophrenia</a>,<sup id="cite_ref-pmid12140778_11-0" class="reference"><a href="#cite_note-pmid12140778-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid16389274_12-0" class="reference"><a href="#cite_note-pmid16389274-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> <a href="Restless_leg_syndrome" class="mw-redirect" title="Restless leg syndrome">restless leg syndrome</a>,<sup id="cite_ref-pmid18058820_13-0" class="reference"><a href="#cite_note-pmid18058820-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> and <a href="Psychostimulant" class="mw-redirect" title="Psychostimulant">psychostimulant</a> neurotoxicity. It has also been investigated with respect to <a href="Bipolar_disorder" title="Bipolar disorder">bipolar disorder</a><sup id="cite_ref-pmid14681919_14-0" class="reference"><a href="#cite_note-pmid14681919-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> and <a href="Air_pollution" title="Air pollution">air pollution</a> exposure.<sup id="cite_ref-Steenackers_15-0" class="reference"><a href="#cite_note-Steenackers-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup>

</p>

<div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2></div>

<p>NOS1 has been shown to <a href="Protein-protein_interaction" class="mw-redirect" title="Protein-protein interaction">interact</a> with <a href="DLG4" title="DLG4">DLG4</a><sup id="cite_ref-pmid9459447_16-0" class="reference"><a href="#cite_note-pmid9459447-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid8625413_17-0" class="reference"><a href="#cite_note-pmid8625413-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> and <a href="NOS1AP" title="NOS1AP">NOS1AP</a>.<sup id="cite_ref-pmid9459447_16-1" class="reference"><a href="#cite_note-pmid9459447-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup>

</p>

<ul><li><a href="Nitric_oxide_synthase" title="Nitric oxide synthase">Nitric oxide synthase</a></li></ul>

<div class="mw-heading mw-heading2"><h2 id="References">References</h2></div>

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<li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000089250">GRCh38: Ensembl release 89: ENSG00000089250</a> – <a href="Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span>

</li>

<li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000029361">GRCm38: Ensembl release 89: ENSMUSG00000029361</a> – <a href="Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span>

</li>

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</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=4842">"Human PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite></span>

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</ol></div>

<div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2></div>

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<ul><li><cite id="CITEREFMiyagoe-SuzukiTakeda2001" class="citation journal cs1">Miyagoe-Suzuki Y, Takeda SI (2001). "Association of neuronal nitric oxide synthase (nNOS) with alpha1-syntrophin at the sarcolemma". <i>Microsc. Res. Tech</i>. <b>55</b> (3): <span class="nowrap">164–</span>70. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fjemt.1167">10.1002/jemt.1167</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11747091">11747091</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:28225242">28225242</a>.</cite></li>

<li><cite id="CITEREFWaddington2002" class="citation journal cs1">Waddington SN (2002). <a rel="nofollow" class="external text" href="https://doi.org/10.1046%2Fj.1523-1755.2002.00236.x">"Arginase in glomerulonephritis"</a>. <i>Kidney Int</i>. <b>61</b> (3): <span class="nowrap">876–</span>81. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1046%2Fj.1523-1755.2002.00236.x">10.1046/j.1523-1755.2002.00236.x</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11849441">11849441</a>.</cite></li>

<li><cite id="CITEREFRotilioAquilanoCiriolo2004" class="citation journal cs1">Rotilio G, Aquilano K, Ciriolo MR (2004). <a rel="nofollow" class="external text" href="https://doi.org/10.1080%2F15216540310001628717">"Interplay of Cu,Zn superoxide dismutase and nitric oxide synthase in neurodegenerative processes"</a>. <i>IUBMB Life</i>. <b>55</b> (<span class="nowrap">10–</span>11): <span class="nowrap">629–</span>34. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1080%2F15216540310001628717">10.1080/15216540310001628717</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/14711010">14711010</a>. <a href="S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:19518719">19518719</a>.</cite></li></ul>

</div>

<p><i>This article incorporates text from the <a href="United_States_National_Library_of_Medicine" title="United States National Library of Medicine">United States National Library of Medicine</a>, which is in the <a href="Public_domain" title="Public domain">public domain</a>.</i>

</p>

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</style><div id="PDB_gallery11" style="font-size:114%;margin:0 4em">PDB gallery</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"><ul class="nochecker gallery mw-gallery-traditional" style="line-height:130%">

<div class="gallerytext"><b>1b8q</b>: SOLUTION STRUCTURE OF THE EXTENDED NEURONAL NITRIC OXIDE SYNTHASE PDZ DOMAIN COMPLEXED WITH AN ASSOCIATED PEPTIDE</div>

</li>

<div class="gallerytext"><b>1f20</b>: CRYSTAL STRUCTURE OF RAT NEURONAL NITRIC-OXIDE SYNTHASE FAD/NADP+ DOMAIN AT 1.9A RESOLUTION.</div>

</li>

<div class="gallerytext"><b>1k2r</b>: Structure of rat brain nNOS heme domain complexed with NG-nitro-L-arginine</div>

</li>

<div class="gallerytext"><b>1k2s</b>: Structure of rat brain nNOS heme domain complexed with NG-allyl-L-arginine</div>

</li>

<div class="gallerytext"><b>1k2t</b>: Structure of rat brain nNOS heme domain complexed with S-ethyl-N-phenyl-isothiourea</div>

</li>

<div class="gallerytext"><b>1k2u</b>: Structure of rat brain nNOS heme domain complexed with S-ethyl-N-[4-(trifluoromethyl)phenyl] isothiourea</div>

</li>

<div class="gallerytext"><b>1lzx</b>: Rat neuronal NOS heme domain with NG-hydroxy-L-arginine bound</div>

</li>

<div class="gallerytext"><b>1lzz</b>: Rat neuronal NOS heme domain with N-isopropyl-N'-hydroxyguanidine bound</div>

</li>

<div class="gallerytext"><b>1m00</b>: Rat neuronal NOS heme domain with N-butyl-N'-hydroxyguanidine bound</div>

</li>

<div class="gallerytext"><b>1mmv</b>: Rat neuronal NOS heme domain with NG-propyl-L-arginine bound</div>

</li>

<div class="gallerytext"><b>1mmw</b>: Rat neuronal NOS heme domain with vinyl-L-NIO bound</div>

</li>

<div class="gallerytext"><b>1om4</b>: STRUCTURE OF RAT NEURONAL NOS HEME DOMAIN WITH L-ARGININE BOUND</div>

</li>

<div class="gallerytext"><b>1om5</b>: STRUCTURE OF RAT NEURONAL NOS HEME DOMAIN WITH 3-BROMO-7-NITROINDAZOLE BOUND</div>

</li>

<div class="gallerytext"><b>1p6h</b>: Rat neuronal NOS heme domain with L-N(omega)-nitroarginine-2,4-L-diaminobutyric amide bound</div>

</li>

<div class="gallerytext"><b>1p6i</b>: Rat neuronal NOS heme domain with (4S)-N-(4-amino-5-[aminoethyl]aminopentyl)-N'-nitroguanidine bound</div>

</li>

<div class="gallerytext"><b>1p6j</b>: Rat neuronal NOS heme domain with L-N(omega)-nitroarginine-(4R)-amino-L-proline amide bound</div>

</li>

<div class="gallerytext"><b>1p6k</b>: Rat neuronal NOS D597N mutant heme domain with L-N(omega)-nitroarginine-2,4-L-diaminobutyric amide bound</div>

</li>

<div class="gallerytext"><b>1qau</b>: UNEXPECTED MODES OF PDZ DOMAIN SCAFFOLDING REVEALED BY STRUCTURE OF NNOS-SYNTROPHIN COMPLEX</div>

</li>

<div class="gallerytext"><b>1qav</b>: Unexpected Modes of PDZ Domain Scaffolding Revealed by Structure of NNOS-Syntrophin Complex</div>

</li>

<div class="gallerytext"><b>1qw6</b>: Rat neuronal nitric oxide synthase oxygenase domain in complex with N-omega-propyl-L-Arg.</div>

</li>

<div class="gallerytext"><b>1qwc</b>: Rat neuronal nitric oxide synthase oxygenase domain in complex with W1400 inhibitor.</div>

</li>

<div class="gallerytext"><b>1rs6</b>: Rat neuronal NOS heme domain with D-lysine-D-nitroarginine amide bound</div>

</li>

<div class="gallerytext"><b>1rs7</b>: Rat neuronal NOS heme domain with D-phenylalanine-D-nitroarginine amide bound</div>

</li>

<div class="gallerytext"><b>1tll</b>: CRYSTAL STRUCTURE OF RAT NEURONAL NITRIC-OXIDE SYNTHASE REDUCTASE MODULE AT 2.3 A RESOLUTION.</div>

</li>

<div class="gallerytext"><b>1vag</b>: Neuronal nitric oxide synthase oxygenase domain complexed with the inhibitor AR-R17477</div>

</li>

<div class="gallerytext"><b>1zvi</b>: Rat Neuronal Nitric Oxide Synthase Oxygenase Domain</div>

</li>

<div class="gallerytext"><b>1zvl</b>: Rat Neuronal Nitric Oxide Synthase Oxygenase Domain complexed with natural substrate L-Arg.</div>

</li>

<div class="gallerytext"><b>1zzq</b>: Rat nNOS D597N mutant with L-N(omega)-Nitroarginine-(4R)-amino-L-proline amide bound</div>

</li>

<div class="gallerytext"><b>1zzr</b>: Rat nNOS D597N/M336V double mutant with L-N(omega)-Nitroarginine-(4R)-amino-L-proline amide bound</div>

</li>

<div class="gallerytext"><b>1zzu</b>: Rat nNOS D597N/M336V double mutant with L-N(omega)-Nitroarginine-2,4-L-Diaminobutyric Amide Bound</div>

</li>

<div class="gallerytext"><b>2g6h</b>: Structure of rat nNOS heme domain (BH4 bound) in the reduced form</div>

</li>

<div class="gallerytext"><b>2g6i</b>: Structure of rat nNOS heme domain (BH2-bound) in the reduced form</div>

</li>

<div class="gallerytext"><b>2g6j</b>: Structure of rat nNOS (L337N) heme domain (4-aminobiopterin bound) complexed with NO</div>

</li>

<div class="gallerytext"><b>2g6k</b>: Structure of rat nNOS heme domain (BH4 bound) complexed with NO</div>

</li>

<div class="gallerytext"><b>2g6l</b>: Structure of rat nNOS heme domain (BH2 bound) complexed with NO</div>

</li>

<div class="gallerytext"><b>2g6m</b>: Structure of rat nNOS heme domain (BH4 bound) complexed with CO</div>

</li>

<div class="gallerytext"><b>2g6n</b>: Structure of rat nNOS heme domain (BH2 bound) complexed with CO</div>

</li>

<div class="gallerytext"><b>2hx3</b>: Rat nNOS heme domain complexed with (4S)-N-{4-Amino-5-[(2-aminoethyl)-hydroxyamino]-pentyl}-N'-nitroguanidine</div>

</li>

<div class="gallerytext"><b>2hx4</b>: Rat nNOS heme domain complexed with 4-N-(Nw-nitro-L-argininyl)-trans-4-hydroxyamino-L-proline amide</div>

</li>

</ul></div></td></tr></tbody></table></div>

<div class="navbox-styles"></div><div role="navigation" class="navbox" aria-labelledby="Oxidoreductases:_dioxygenases,_including_steroid_hydroxylases_(EC_1.14)1528" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Oxidoreductases:_dioxygenases,_including_steroid_hydroxylases_(EC_1.14)1528" style="font-size:114%;margin:0 4em"><a href="Oxidoreductase" title="Oxidoreductase">Oxidoreductases</a>: <a href="Oxygenase" title="Oxygenase">dioxygenases</a>, including <a href="Steroid_hydroxylases" class="mw-redirect" title="Steroid hydroxylases">steroid hydroxylases</a> (<a href="Enzyme_Commission_number" title="Enzyme Commission number">EC</a> 1.14)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="List_of_EC_numbers_(EC_1)#EC_1.14.11_With_2-oxoglutarate_as_one_donor.2C_and_incorporation_of_one_atom_each_of_oxygen_into_both_donors" title="List of EC numbers (EC 1)">1.14.11</a>: <a href="Alpha-Ketoglutaric_acid" class="mw-redirect" title="Alpha-Ketoglutaric acid">2-oxoglutarate</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Prolyl_hydroxylase" class="mw-redirect" title="Prolyl hydroxylase">Prolyl hydroxylase</a>

<ul><li><a href="HIF_prolyl-hydroxylase" class="mw-redirect" title="HIF prolyl-hydroxylase">HIF prolyl-hydroxylase</a>

<li><a href="Lysyl_hydroxylase" title="Lysyl hydroxylase">Lysyl hydroxylase</a></li>

<ul><li><a href="Alkb_homolog_1%2C_histone_h2a_dioxygenase" title="Alkb homolog 1, histone h2a dioxygenase">ALKBH1</a></li>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="List_of_EC_numbers_(EC_1)#EC_1.14.13_With_NADH_or_NADPH_as_one_donor.2C_and_incorporation_of_one_atom_of_oxygen" title="List of EC numbers (EC 1)">1.14.13</a>: <a href="NADH" class="mw-redirect" title="NADH">NADH</a> or <a href="NADPH" class="mw-redirect" title="NADPH">NADPH</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Flavin-containing_monooxygenase" title="Flavin-containing monooxygenase">Flavin-containing monooxygenase</a>

<li><a href="Nitric_oxide_synthase" title="Nitric oxide synthase">Nitric oxide synthase</a>

<ul>

<li><a href="Cholesterol_7_alpha-hydroxylase" title="Cholesterol 7 alpha-hydroxylase">Cholesterol 7 alpha-hydroxylase</a></li>

<li><a href="Methane_monooxygenase" title="Methane monooxygenase">Methane monooxygenase</a></li>

<li><a href="14%CE%B1-demethylase" class="mw-redirect" title="14α-demethylase">14α-demethylase</a></li>

<li><a href="24-hydroxycholesterol_7alpha-hydroxylase" title="24-hydroxycholesterol 7alpha-hydroxylase">24-hydroxycholesterol 7α-hydroxylase</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="List_of_EC_numbers_(EC_1)#EC_1.14.14_With_reduced_flavin_or_flavoprotein_as_one_donor.2C_and_incorporation_of_one_atom_of_oxygen" title="List of EC numbers (EC 1)">1.14.14</a>: reduced <a href="Flavin_group" title="Flavin group">flavin</a> or <a href="Flavoprotein" title="Flavoprotein">flavoprotein</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em">

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="List_of_EC_numbers_(EC_1)#EC_1.14.15_With_reduced_iron–sulfur_protein_as_one_donor.2C_and_incorporation_of_one_atom_of_oxygen" title="List of EC numbers (EC 1)">1.14.15</a>: reduced <a href="Iron%E2%80%93sulfur_protein" title="Iron–sulfur protein">iron–sulfur protein</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em">

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="List_of_EC_numbers_(EC_1)#EC_1.14.16_With_reduced_pteridine_as_one_donor.2C_and_incorporation_of_one_atom_of_oxygen" title="List of EC numbers (EC 1)">1.14.16</a>: reduced <a href="Pteridine" title="Pteridine">pteridine</a> (<a href="Tetrahydrobiopterin" title="Tetrahydrobiopterin">BH4 dependent</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Phenylalanine_hydroxylase" title="Phenylalanine hydroxylase">Phenylalanine hydroxylase</a></li>

<li><a href="Tyrosine_hydroxylase" title="Tyrosine hydroxylase">Tyrosine hydroxylase</a></li>

<li><a href="Tryptophan_hydroxylase" title="Tryptophan hydroxylase">Tryptophan hydroxylase</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="List_of_EC_numbers_(EC_1)#EC_1.14.17_With_reduced_ascorbate_as_one_donor.2C_and_incorporation_of_one_atom_of_oxygen" title="List of EC numbers (EC 1)">1.14.17</a>: reduced <a href="Ascorbate" class="mw-redirect" title="Ascorbate">ascorbate</a></th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Dopamine_beta-hydroxylase" title="Dopamine beta-hydroxylase">Dopamine beta-hydroxylase</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="List_of_EC_numbers_(EC_1)#EC_1.14.18_With_another_compound_as_one_donor.2C_and_incorporation_of_one_atom_of_oxygen" title="List of EC numbers (EC 1)">1.14.18</a>-<a href="List_of_EC_numbers_(EC_1)#EC_1.14.19_With_oxidation_of_a_pair_of_donors_resulting_in_the_reduction_of_molecular_oxygen_to_two_molecules_of_water" title="List of EC numbers (EC 1)">19</a>: other</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Tyrosinase" title="Tyrosinase">Tyrosinase</a></li>

<li><a href="Stearoyl-CoA_desaturase-1" class="mw-redirect" title="Stearoyl-CoA desaturase-1">Stearoyl-CoA desaturase-1</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="List_of_EC_numbers_(EC_1)#EC_1.14.99_Miscellaneous" title="List of EC numbers (EC 1)">1.14.99</a> - miscellaneous</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Cyclooxygenase" title="Cyclooxygenase">Cyclooxygenase</a></li>

<li><a href="Heme_oxygenase" title="Heme oxygenase">Heme oxygenase</a> (<a href="HMOX1" title="HMOX1">HMOX1</a>)</li>

<li><a href="Squalene_monooxygenase" title="Squalene monooxygenase">Squalene monooxygenase</a></li>

<li><a href="Ecdysone_20-monooxygenase" title="Ecdysone 20-monooxygenase">Ecdysone 20-monooxygenase</a></li>

<li><a href="Deoxyhypusine_monooxygenase" title="Deoxyhypusine monooxygenase">Deoxyhypusine monooxygenase</a></li></ul>

</div></td></tr></tbody></table></div>

<div class="navbox-styles"></div><div role="navigation" class="navbox" aria-labelledby="Enzymes_involved_in_neurotransmission167" style="padding:3px"><table class="nowraplinks hlist mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Enzymes_involved_in_neurotransmission167" style="font-size:114%;margin:0 4em"><a href="Enzyme" title="Enzyme">Enzymes</a> involved in <a href="Neurotransmitter" title="Neurotransmitter">neurotransmission</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Monoamine_neurotransmitter" title="Monoamine neurotransmitter">monoamine</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Histidine" title="Histidine">histidine</a> → <a href="Histamine" title="Histamine">histamine</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>anabolism:</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Histidine_decarboxylase" title="Histidine decarboxylase">Histidine decarboxylase</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>catabolism:</i></span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Histamine_N-methyltransferase" title="Histamine N-methyltransferase">Histamine N-methyltransferase</a></li>

<li><a href="Diamine_oxidase" title="Diamine oxidase">Diamine oxidase</a></li></ul>

</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Tyrosine" title="Tyrosine">tyrosine</a>→<a href="Dopamine" title="Dopamine">dopamine</a>→<a href="Epinephrine" class="mw-redirect" title="Epinephrine">epinephrine</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>anabolism:</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Tyrosine_hydroxylase" title="Tyrosine hydroxylase">Tyrosine hydroxylase</a></li>

<li><a href="Aromatic_L-amino_acid_decarboxylase" title="Aromatic L-amino acid decarboxylase">Aromatic <small>L</small>-amino acid decarboxylase</a></li>

<li><a href="Dopamine_beta-hydroxylase" title="Dopamine beta-hydroxylase">Dopamine beta-hydroxylase</a></li>

<li><a href="Phenylethanolamine_N-methyltransferase" title="Phenylethanolamine N-methyltransferase">Phenylethanolamine N-methyltransferase</a></li></ul>

<ul><li><a href="Catechol-O-methyl_transferase" class="mw-redirect" title="Catechol-O-methyl transferase">Catechol-O-methyl transferase</a></li>

<li><a href="Monoamine_oxidase" title="Monoamine oxidase">Monoamine oxidase</a>

</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Glutamic_acid" title="Glutamic acid">glutamate</a>→<a href="Gamma-Aminobutyric_acid" class="mw-redirect" title="Gamma-Aminobutyric acid">GABA</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>anabolism:</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Glutamate_decarboxylase" title="Glutamate decarboxylase">Glutamate decarboxylase</a></li></ul>

<ul><li><a href="4-aminobutyrate_transaminase" title="4-aminobutyrate transaminase">4-aminobutyrate transaminase</a></li></ul>

</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Tryptophan" title="Tryptophan">tryptophan</a>→<a href="Serotonin" title="Serotonin">serotonin</a>→<a href="Melatonin" title="Melatonin">melatonin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Tryptophan_hydroxylase" title="Tryptophan hydroxylase">Tryptophan hydroxylase</a></li>

<li><a href="Aromatic_L-amino_acid_decarboxylase" title="Aromatic L-amino acid decarboxylase">Aromatic <small>L</small>-amino acid decarboxylase</a></li>

<li><a href="Aralkylamine_N-acetyltransferase" title="Aralkylamine N-acetyltransferase">Aralkylamine N-acetyltransferase</a></li>

<li><a href="Acetylserotonin_O-methyltransferase" title="Acetylserotonin O-methyltransferase">Acetylserotonin O-methyltransferase</a></li></ul>

</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Arginine" title="Arginine">arginine</a>→<a href="Nitric_oxide" title="Nitric oxide">NO</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Nitric_oxide_synthase" title="Nitric oxide synthase">Nitric oxide synthase</a> (, <a href="Nitric_oxide_synthase_2_(inducible)" title="Nitric oxide synthase 2 (inducible)">NOS2</a>, <a href="Endothelial_NOS" title="Endothelial NOS">NOS3</a>)</li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="Choline" title="Choline">choline</a>→<a href="Acetylcholine" title="Acetylcholine">Acetylcholine</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><span class="nobold"><i>anabolism:</i></span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Choline_acetyltransferase" title="Choline acetyltransferase">Choline acetyltransferase</a></li></ul>

<ul><li><a href="Cholinesterase" title="Cholinesterase">Cholinesterase</a> (<a href="Acetylcholinesterase" title="Acetylcholinesterase">Acetylcholinesterase</a>, <a href="Butyrylcholinesterase" title="Butyrylcholinesterase">Butyrylcholinesterase</a>)</li></ul>

</div></td></tr></tbody></table><div></div></td></tr></tbody></table></div>

<div class="navbox-styles"></div><div role="navigation" class="navbox" aria-labelledby="Enzymes56" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Enzymes56" style="font-size:114%;margin:0 4em"><a href="Enzyme" title="Enzyme">Enzymes</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Activity</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Active_site" title="Active site">Active site</a></li>

<li><a href="Binding_site" title="Binding site">Binding site</a></li>

<li><a href="Catalytic_triad" title="Catalytic triad">Catalytic triad</a></li>

<li><a href="Oxyanion_hole" title="Oxyanion hole">Oxyanion hole</a></li>

<li><a href="Enzyme_promiscuity" title="Enzyme promiscuity">Enzyme promiscuity</a></li>

<li><a href="Diffusion-limited_enzyme" title="Diffusion-limited enzyme">Diffusion-limited enzyme</a></li>

<li><a href="Cofactor_(biochemistry)" title="Cofactor (biochemistry)">Cofactor</a></li>

<li><a href="Enzyme_catalysis" title="Enzyme catalysis">Enzyme catalysis</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Regulation</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Allosteric_regulation" title="Allosteric regulation">Allosteric regulation</a></li>

<li><a href="Cooperativity" title="Cooperativity">Cooperativity</a></li>

<li><a href="Enzyme_inhibitor" title="Enzyme inhibitor">Enzyme inhibitor</a></li>

<li><a href="Enzyme_activator" title="Enzyme activator">Enzyme activator</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Classification</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Enzyme_Commission_number" title="Enzyme Commission number">EC number</a></li>

<li><a href="Protein_superfamily" title="Protein superfamily">Enzyme superfamily</a></li>

<li><a href="Protein_family" title="Protein family">Enzyme family</a></li>

<li><a href="List_of_enzymes" title="List of enzymes">List of enzymes</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Kinetics</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Enzyme_kinetics" title="Enzyme kinetics">Enzyme kinetics</a></li>

<li><a href="Eadie%E2%80%93Hofstee_diagram" title="Eadie–Hofstee diagram">Eadie–Hofstee diagram</a></li>

<li><a href="Hanes%E2%80%93Woolf_plot" title="Hanes–Woolf plot">Hanes–Woolf plot</a></li>

<li><a href="Lineweaver%E2%80%93Burk_plot" title="Lineweaver–Burk plot">Lineweaver–Burk plot</a></li>

<li><a href="Michaelis%E2%80%93Menten_kinetics" title="Michaelis–Menten kinetics">Michaelis–Menten kinetics</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Types</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><b>EC1 <a href="Oxidoreductase" title="Oxidoreductase">Oxidoreductases</a></b> (<a href="List_of_EC_numbers_(EC_1)" title="List of EC numbers (EC 1)">list</a>)</li>

<li><b>EC2 <a href="Transferase" title="Transferase">Transferases</a></b> (<a href="List_of_EC_numbers_(EC_2)" title="List of EC numbers (EC 2)">list</a>)</li>

<li><b>EC3 <a href="Hydrolase" title="Hydrolase">Hydrolases</a></b> (<a href="List_of_EC_numbers_(EC_3)" title="List of EC numbers (EC 3)">list</a>)</li>

<li><b>EC4 <a href="Lyase" title="Lyase">Lyases</a></b> (<a href="List_of_EC_numbers_(EC_4)" title="List of EC numbers (EC 4)">list</a>)</li>

<li><b>EC5 <a href="Isomerase" title="Isomerase">Isomerases</a></b> (<a href="List_of_EC_numbers_(EC_5)" title="List of EC numbers (EC 5)">list</a>)</li>

<li><b>EC6 <a href="Ligase" title="Ligase">Ligases</a></b> (<a href="List_of_EC_numbers_(EC_6)" title="List of EC numbers (EC 6)">list</a>)</li>

<li><b>EC7 <a href="Translocase" title="Translocase">Translocases</a></b> (<a href="List_of_EC_numbers_(EC_7)" title="List of EC numbers (EC 7)">list</a>)</li></ul>

</div></td></tr></tbody></table></div>

<div class="navbox-styles"></div><div role="navigation" class="navbox" aria-labelledby="Nitric_oxide_signaling_modulators330" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Nitric_oxide_signaling_modulators330" style="font-size:114%;margin:0 4em"><a href="Nitric_oxide" title="Nitric oxide">Nitric oxide</a> <a href="Cell_signaling" title="Cell signaling">signaling</a> <a href="Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="Nitric_oxide" title="Nitric oxide">Forms</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Nitroxyl" title="Nitroxyl">Nitroxyl anion (NO<sup>−</sup>; oxonitrate(1-), hyponitrite anion)</a></li>

<li><a href="Nitric_oxide" title="Nitric oxide">Nitric oxide (NO<sup>⋅</sup>; nitrogen monoxide)</a></li>

<li><a href="Nitrosonium" title="Nitrosonium">Nitrosonium (NO<sup>+</sup>; nitrosyl cation)</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="Biological_target" title="Biological target">Targets</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="sGC33" scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="Soluble_guanylate_cyclase" class="mw-redirect" title="Soluble guanylate cyclase">sGC</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><i>Activators/stimulators:</i> Ataciguat</li>

<li><a href="Cinaciguat" title="Cinaciguat">Cinaciguat (BAY 58-2667)</a></li>

<li>Praliciguat</li>

<li><a href="Riociguat" title="Riociguat">Riociguat</a></li>

<li><a href="Vericiguat" title="Vericiguat">Vericiguat</a></li></ul>

<ul><li><i>Inhibitors:</i> ODQ</li></ul>

</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="NO_donor" class="mw-redirect" title="NO donor">NO donors</a><br><small>(<a href="Prodrug" title="Prodrug">prodrugs</a>)</small></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><i><a href="Nitrate" title="Nitrate">Nitrates</a>:</i> <a href="Diethylene_glycol_dinitrate" title="Diethylene glycol dinitrate">Diethylene glycol dinitrate (DEGDN)</a></li>

<li><a href="Erythritol_tetranitrate" title="Erythritol tetranitrate">Erythritol tetranitrate (ETN)</a></li>

<li><a href="Ethylene_glycol_dinitrate" title="Ethylene glycol dinitrate">Ethylene glycol dinitrate (EGDN; nitroglycol)</a></li>

<li><a href="Isosorbide_mononitrate" title="Isosorbide mononitrate">Isosorbide mononitrate (ISMN)</a></li>

<li><a href="Isosorbide_dinitrate" title="Isosorbide dinitrate">Isosorbide dinitrate (ISDN)</a></li>

<li><a href="Itramin_tosilate" title="Itramin tosilate">Itramin tosilate</a></li>

<li><a href="Mannitol_hexanitrate" title="Mannitol hexanitrate">Mannitol hexanitrate</a></li>

<li><a href="Naproxcinod" title="Naproxcinod">Naproxcinod (nitronaproxen; AZD-3582, HCT-3012)</a></li>

<li><a href="Nicorandil" title="Nicorandil">Nicorandil</a></li>

<li><a href="Nipradilol" title="Nipradilol">Nipradilol (K-351)</a></li>

<li><a href="Nitrate" title="Nitrate">Nitrate (NO<span class="nowrap"><span style="display:inline-block;margin-bottom:-0.3em;vertical-align:-0.4em;line-height:1.2em;font-size:80%;text-align:left"><sup style="font-size:inherit;line-height:inherit;vertical-align:baseline">−</sup><br><sub style="font-size:inherit;line-height:inherit;vertical-align:baseline">3</sub></span></span>)</a></li>

<li>Nitroatorvastatin (NCX-6560)</li>

<li>Nitroflurbiprofen (HCT-1026)</li>

<li>Nitrofluvastatin</li>

<li><a href="Nitroglycerin_(drug)" class="mw-redirect" title="Nitroglycerin (drug)">Nitroglycerin (glyceryl trinitrate (GTN))</a></li>

<li>Nitropravastatin (NCX-6550)</li>

<li><a href="Pentaerithrityl_tetranitrate" class="mw-redirect" title="Pentaerithrityl tetranitrate">Pentaerithrityl tetranitrate (PETN)</a></li>

<li><a href="Propatylnitrate" title="Propatylnitrate">Propatylnitrate</a></li>

<li><a href="Propylene_glycol_dinitrate" title="Propylene glycol dinitrate">Propylene glycol dinitrate (PGDN)</a></li>

<li>Sodium trioxodinitrate (Angeli's salt)</li>

<li>Tenitramine</li>

<li><a href="Trolnitrate" title="Trolnitrate">Trolnitrate</a></li></ul>

<ul><li><i><a href="Nitroso_compound" class="mw-redirect" title="Nitroso compound">Nitroso compounds</a>/<a href="Nitrite" title="Nitrite">nitrites</a>:</i> <a href="Nitrite" title="Nitrite">Nitrite (NO<span class="nowrap"><span style="display:inline-block;margin-bottom:-0.3em;vertical-align:-0.4em;line-height:1.2em;font-size:80%;text-align:left"><sup style="font-size:inherit;line-height:inherit;vertical-align:baseline">−</sup><br><sub style="font-size:inherit;line-height:inherit;vertical-align:baseline">2</sub></span></span>)</a>; <i>O-Nitroso compounds (<a href="Alkyl_nitrite" title="Alkyl nitrite">alkyl nitrites</a>):</i> <a href="Amyl_nitrite" title="Amyl nitrite">Amyl nitrite (isoamyl nitrite, isopentyl nitrite)</a></li>

<li><a href="Cyclohexyl_nitrite" title="Cyclohexyl nitrite">Cyclohexyl nitrite</a></li>

<li><a href="Ethyl_nitrite" title="Ethyl nitrite">Ethyl nitrite</a></li>

<li><a href="Hexyl_nitrite" title="Hexyl nitrite">Hexyl nitrite</a></li>

<li><a href="Isobutyl_nitrite" title="Isobutyl nitrite">Isobutyl nitrite (2-methylpropyl nitrite)</a></li>

<li><a href="Isopropyl_nitrite" title="Isopropyl nitrite">Isopropyl nitrite</a></li>

<li><a href="Methyl_nitrite" title="Methyl nitrite">Methyl nitrite</a></li>

<li><a href="Butyl_nitrite" title="Butyl nitrite"><i>n</i>-Butyl nitrite</a></li>

<li><a href="Pentyl_nitrite" title="Pentyl nitrite">Pentyl nitrite</a></li>

<li><a href="Tert-Butyl_nitrite" title="Tert-Butyl nitrite"><i>tert</i>-Butyl nitrite</a>; <i><a href="S-Nitrosothiol" title="S-Nitrosothiol">S-Nitroso compounds</a> (thionitrites):</i> LA810</li>

<li>S-Nitrosoalbumin (SNALB)</li>

<li>S-Nitrosated AR545C</li>

<li>S-Nitroso-N-acetylcysteine (SNAC)</li>

<li><a href="S-Nitroso-N-acetylpenicillamine" title="S-Nitroso-N-acetylpenicillamine">S-Nitroso-N-acetylpenicillamine (SNAP)</a></li>

<li>S-Nitroso-N-valerylpenicillamine (SNVP)</li>

<li>S-Nitrosocaptopril (SNO-Cap)</li>

<li>S-Nitrosocysteine (SNC, CysNO, SNO-Cys)</li>

<li>S-Nitrosodiclofenac</li>

<li><a href="S-Nitrosoglutathione" title="S-Nitrosoglutathione">S-Nitrosoglutathione (GSNO, SNOG)</a></li>

<li>SNO-vWF; <i>N-Nitroso compounds (e.g., <a href="Nitrosamine" title="Nitrosamine">nitrosamines</a>):</i> SIN-1A</li></ul>

<ul><li><i>Nitrosyl compounds:</i> <i><a href="Metal_nitrosyl_complex" title="Metal nitrosyl complex">Metal nitrosyl complexes</a>:</i> <a href="Roussin's_black_salt" title="Roussin's black salt">Roussin's black salt</a></li>

<li><a href="Roussin's_red_salt" title="Roussin's red salt">Roussin's red salt</a></li>

<li><a href="Sodium_nitroprusside" title="Sodium nitroprusside">Sodium nitroprusside (SNP)</a></li></ul>

<ul><li><i><a href="NONOate" title="NONOate">NONOates</a> (diazeniumdiolates):</i> Diethylamine/NO (DEA/NO)</li>

<li>Diethylenetriamine/NO (DETA/NO)</li>

<li>Methylamine hexamethylene methylamine/NO (MAHMA/NO)</li>

<li>PROLI/NO</li>

<li>Spermine/NO (SPER/NO)</li>

<li>V-PYRRO/NO</li></ul>

<ul><li><i>Heterocyclic compounds:</i> <i><a href="Furoxan" title="Furoxan">Furoxans</a>:</i> <a href="Furoxan" title="Furoxan">Furoxan</a></li>

<li>REC15/2739; <i>Sydnonimines:</i> <a href="Feprosidnine" title="Feprosidnine">Feprosidnine</a></li>

<li><a href="Linsidomine" title="Linsidomine">Linsidomine (SIN-1)</a></li>

<li><a href="Molsidomine" title="Molsidomine">Molsidomine (SIN-10)</a></li>

<li>Sydnonimine</li></ul>

<ul><li><i>Unsorted:</i> <a href="Cimlanod" title="Cimlanod">Cimlanod</a></li>

<li>N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide</li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="Enzyme" title="Enzyme">Enzyme</a><br><small>(<a href="Enzyme_inhibitor" title="Enzyme inhibitor">inhibitors</a>)</small></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="Nitric_oxide_synthase" title="Nitric oxide synthase">NOS</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li>3-Bromo-7-nitroindazole</li>

<li>3-Chloroindazole</li>

<li>3-Chloro-5-nitroindazole</li>

<li>5-Nitroindazole</li>

<li>6-Nitroindazole</li>

<li><a href="7-Nitroindazole" title="7-Nitroindazole">7-Nitroindazole</a></li>

<li><a href="Aminoguanidine" class="mw-redirect" title="Aminoguanidine">Aminoguanidine (pimagedine)</a></li>

<li><a href="Indazole" title="Indazole">Indazole</a></li>

<li>N<sup>5</sup>-(1-Iminoethyl)-L-ornithine (<small>L</small>-NIO)</li>

<li>N<sup>ω</sup>-Methyl-<small>L</small>-arginine (<small>L</small>-NMA)</li>

<li>N<sup>ω</sup>-Propyl-<small>L</small>-arginine (<small>L</small>-NPA)</li>

<li><a href="Nitroarginine" title="Nitroarginine">Nitroarginine (NNA, NOARG)</a></li>

<li><a href="Pentamidine_isethionate" class="mw-redirect" title="Pentamidine isethionate">Pentamidine isethionate</a></li>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="Nitric_oxide_synthase_2_(inducible)" title="Nitric oxide synthase 2 (inducible)">iNOS</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li>1-Amino-2-hydroxyguanidine</li>

<li>2-Ethylaminoguanidine</li>

<li>2-Iminopiperidine</li>

<li>AEITU</li>

<li><a href="Aminoguanidine" class="mw-redirect" title="Aminoguanidine">Aminoguanidine (pimagedine)</a></li>

<li><a href="Canavanine" title="Canavanine">Canavanine</a></li>

<li>Cindunistat (SD-6010)</li>

<li>N<sup>5</sup>-(1-Iminoethyl)-<small>L</small>-ornithine (<small>L</small>-NIO)</li>

<li>N<sup>6</sup>-(1-Iminoethyl)-<small>L</small>-lysine (<small>L</small>-NIL)</li>

<li>N<sup>ω</sup>-Methyl-<small>L</small>-arginine (<small>L</small>-NMA)</li>

<li>Ronopterin (VAS-203)</li>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="Endothelial_NOS" title="Endothelial NOS">eNOS</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Aminoguanidine" class="mw-redirect" title="Aminoguanidine">Aminoguanidine (pimagedine)</a></li>

<li>N<sup>5</sup>-(1-Iminoethyl)-<small>L</small>-ornithine (<small>L</small>-NIO)</li>

<li>N<sup>ω</sup>-Methyl-<small>L</small>-arginine (<small>L</small>-NMA)</li>

<li><a href="Nitroarginine" title="Nitroarginine">Nitroarginine (NNA, NOARG)</a></li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Unsorted</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><a href="Asymmetric_dimethylarginine" title="Asymmetric dimethylarginine">Asymmetric dimethylarginine (ADMA)</a></li>

<li>Guanidinoethyldisulfide (GED)</li>

<li><a href="Indospicine" title="Indospicine">Indospicine</a></li>

<li>Nitroarginine methyl ester (NAME)</li>

</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="Arginase" title="Arginase">Arginase</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em">

<li>N<sup>ω</sup>-Hydroxy-<small>L</small>-arginine (NOHA)</li>

<li><a href="Chlorogenic_acid" title="Chlorogenic acid">chlorogenic acid</a></li>

<li><a href="Ginseng" title="Ginseng">ginseng</a></li>

<li><a href="Epicatechin" class="mw-redirect" title="Epicatechin">epicatechin</a></li>

<li><a href="Ornithine" title="Ornithine">ornithine</a></li>

<li><a href="Norvaline" title="Norvaline">norvaline</a></li>

<li><a href="Lysine" title="Lysine">lysine</a></li>

<li>alpha aminoacids</li></ul>

</div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="CAMK" title="CAMK">CAMK</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li>Calmidazolium</li>

</div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em">

<ul><li><i>Precursors:</i> <a href="Arginine" title="Arginine"><small>L</small>-Arginine</a></li>

<li>N<sup>ω</sup>-Hydroxy-<small>L</small>-arginine (NOHA)</li></ul>

<ul><li><i>Cofactors:</i> <a href="Nicotinamide_adenine_dinucleotide_phosphate" title="Nicotinamide adenine dinucleotide phosphate">NADPH</a></li>

<ul><li><i>Indirect/downstream NO modulators:</i> <a href="ACE_inhibitor" title="ACE inhibitor">ACE inhibitors</a>/<a href="Angiotensin_II_receptor_antagonist" class="mw-redirect" title="Angiotensin II receptor antagonist">AT-II receptor antagonists</a> (e.g., <a href="Captopril" title="Captopril">captopril</a>, <a href="Losartan" title="Losartan">losartan</a>)</li>

<li><a href="Endothelin_receptor_antagonist" title="Endothelin receptor antagonist">ET<sub>B</sub> receptor antagonists</a> (e.g., <a href="Bosentan" title="Bosentan">bosentan</a>)</li>

<li><a href="L-Type_calcium_channel" class="mw-redirect" title="L-Type calcium channel">L-Type calcium channel</a> <a href="Calcium_channel_blocker" title="Calcium channel blocker">blockers</a> (e.g., <a href="Dihydropyridine" class="mw-redirect" title="Dihydropyridine">dihydropyridines</a>: <a href="Nifedipine" title="Nifedipine">nifedipine</a>)</li>

<li><a href="Nebivolol" title="Nebivolol">Nebivolol</a> (<a href="Beta_blocker" title="Beta blocker">beta blocker</a>)</li>

<li><a href="PDE5_inhibitor" title="PDE5 inhibitor">PDE5 inhibitors</a> (e.g., <a href="Sildenafil" title="Sildenafil">sildenafil</a>)</li>

<li>non-selective PDE inhibitors (e.g., <a href="Caffeine" title="Caffeine">caffeine</a>)</li>

<li>PDE9 inhibitors (e.g., <a href="Paraxanthine" title="Paraxanthine">paraxanthine</a>)</li>

<li>cGMP preferring PDE inhibitors (e.g., sildenafil, paraxanthine, tadalafil)</li>

<li><a href="Statin" title="Statin">Statins</a> (e.g., <a href="Simvastatin" title="Simvastatin">simvastatin</a>)</li></ul>

</div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div><i><b>See also:</b> Receptor/signaling modulators</i></div></td></tr></tbody></table></div>

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